I ship nontrivial PyQt apps. PyQt can basically do anything Qt can do. Multiple inheritance of QWidgets can be dicey, but desired results can usually be achieved by defining mixins that don't subclass QWidget. It works brilliantly, far from "the point of uselessness". For me, cross platform GUIs are a solved problem, and I really can't wrap my head around all the noise to the contrary, or the claims that electron is what saved us.
I don't use PyQt's documentation (wasn't even aware it really existed), it's such a literal wrapper that you can just use Qt's documentation.
And the only churn was a change about five years ago from a less pythonic API (using wrapped Qt types for most things) to a more pythonic one (using Python's native types where it makes sense). And that wasn't even that bad. Other than that it has no more churn than Qt itself does.
